GHRP-6 (10 mg Vial) Dosage Protocol
GHRP-6 is a hexapeptide GH releasing peptide and one of the earliest GHRPs studied. It produces potent GH release via ghrelin receptors and is notable for causing strong appetite stimulation — the most pronounced of any GHRP — through direct hypothalamic ghrelin receptor activation.
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Dosing & Reconstitution Guide
Route: Subcutaneous | Frequency: 2–3× daily, empty stomach
| Week | Dose Per Injection | Frequency | U-100 Units |
|---|---|---|---|
| Weeks 1–2 | 100 mcg | Twice daily | 3 units |
| Weeks 3–4 | 150–200 mcg | Twice daily | 4.5–6 units |
| Weeks 5–12 | 200–300 mcg | 2–3× daily | 6–9 units |
Reconstitution Steps
- Draw 3.0 mL bacteriostatic water.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl until dissolved. Do not shake.
- Refrigerate at 2–8°C; use within 28 days.
Supplies Planning
| Item | 8 Weeks (2×/day) | 12 Weeks (3×/day) |
|---|---|---|
| GHRP-6 vials (10 mg each) | 5 vials | 10 vials |
| Insulin syringes (30–50 unit) | 112 | 252 |
| Bacteriostatic water (10 mL) | 2 × 10 mL | 4 × 10 mL |
| Alcohol swabs | 2–3 × 100-pack | 4–5 × 100-pack |
Mechanism of Action
GHRP-6 is one of the oldest and most studied GHRPs. Like GHRP-2, it acts as an agonist at the ghrelin receptor (GHS-R1a) in both the pituitary and hypothalamus, producing potent GH secretion. Its distinctive pharmacological feature is its robust appetite stimulation — more pronounced than any other GHRP due to its activity profile at hypothalamic ghrelin receptors.
GHRP-6 also elevates cortisol and prolactin, particularly at higher doses, similar to GHRP-2. When combined with GHRH analogs (CJC-1295, Sermorelin), the synergistic GH release can be substantial. The appetite stimulation makes GHRP-6 particularly relevant for research protocols where increased caloric intake is a desired secondary effect.
Research Findings & Safety Profile
- One of the earliest and most studied GHRPs; established the class of ghrelin receptor agonists.
- Produces strong GH pulses comparable to GHRP-2; strong cortisol and prolactin elevation at higher doses.
- Most pronounced appetite stimulation of any GHRP — ghrelin receptor activation drives hunger directly.
- Synergistic with GHRH analogs for amplified GH pulse amplitude.
- Possible effects: strong hunger 20–30 min post-injection, water retention, transient cortisol elevation, tingling.
- Not recommended in contexts where caloric control is critical, due to appetite stimulation profile.
Storage
| State | Temperature | Duration | Notes |
|---|---|---|---|
| Lyophilized | −20°C (−4°F) | Up to 24 months | Dry, dark conditions |
| Reconstituted | 2–8°C (35–46°F) | Up to 28 days | Avoid freeze-thaw |