Ipamorelin (10 mg Vial) Dosage Protocol
Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) and selective growth hormone secretagogue. Identified as the first highly selective GHRP, it stimulates GH release through ghrelin receptors without significantly elevating cortisol, ACTH, or prolactin — a key advantage over earlier GHRPs.
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Dosing & Reconstitution Guide
Route: Subcutaneous | Frequency: 1–3× daily, typically on empty stomach
| Week | Dose Per Injection | Frequency | U-100 Units |
|---|---|---|---|
| Weeks 1–2 | 100 mcg | Once daily | 3 units |
| Weeks 3–4 | 150–200 mcg | Once or twice daily | 4.5–6 units |
| Weeks 5–12 | 200–300 mcg | Once or twice daily | 6–9 units |
Reconstitution Steps
- Draw 3.0 mL bacteriostatic water.
- Inject slowly down the inside glass wall; avoid foaming.
- Gently swirl until dissolved. Do not shake.
- Refrigerate at 2–8°C; use within 28 days.
Supplies Planning
| Item | 8 Weeks (once daily) | 12 Weeks (twice daily) |
|---|---|---|
| Ipamorelin vials (10 mg each) | 2 vials | 6 vials |
| Insulin syringes (30–50 unit) | 56 | 168 |
| Bacteriostatic water (10 mL) | 1 × 10 mL | 2–3 × 10 mL |
| Alcohol swabs | 2 × 100-pack | 3 × 100-pack |
Mechanism of Action
Ipamorelin is a fifth-generation growth hormone releasing peptide (GHRP) that acts as an agonist at the ghrelin receptor (GHS-R1a) in the pituitary gland. It produces a rapid, selective GH pulse peaking approximately 40 minutes post-injection with a duration of approximately 3 hours.
Unlike earlier GHRPs (GHRP-2, GHRP-6, hexarelin), ipamorelin does not significantly stimulate cortisol, ACTH, or prolactin at standard research doses. This selectivity profile is its primary distinguishing characteristic and makes extended-cycle protocols more feasible. When combined with CJC-1295 (No DAC) or other GHRH analogs, synergistic GH pulse amplification is observed, as the two compounds act on complementary receptor pathways.
Research Findings & Safety Profile
- Ipamorelin identified as the first selective GH secretagogue — stimulates GH without significant cortisol, ACTH, or prolactin elevation at standard doses.
- Peak GH pulse at ~40 minutes post-injection; returns to baseline within 3 hours — matching endogenous pulsatile patterns.
- Once-daily ipamorelin normalized growth in GHRH knockout mouse models.
- Well-tolerated in research settings; low desensitization profile compared to earlier GHRPs.
- Possible effects: transient water retention, increased appetite (less than GHRP-6), mild headache or flushing.
- Synergistic GH release when co-administered with GHRH analogs (CJC-1295, Sermorelin).
Storage
| State | Temperature | Duration | Notes |
|---|---|---|---|
| Lyophilized | −20°C (−4°F) | Up to 24 months | Dry, dark conditions |
| Reconstituted | 2–8°C (35–46°F) | Up to 28 days | Avoid freeze-thaw |