GHRP-2 / Pralmorelin (10 mg Vial) Dosage Protocol
GHRP-2 (Pralmorelin) is a synthetic hexapeptide GH releasing peptide that acts on ghrelin receptors in both the pituitary and hypothalamus. It is among the most potent GHRPs studied, producing robust GH release; unlike ipamorelin, it can mildly elevate cortisol and prolactin at higher doses.
âš¡ Quickstart Highlights
Dosing & Reconstitution Guide
Route: Subcutaneous or IV | Frequency: 1–3× daily, empty stomach
| Protocol | Dose Per Injection | Frequency | U-100 Units | Notes |
|---|---|---|---|---|
| Conservative | 100 mcg | Once daily | 3 units | Minimal cortisol effect |
| Standard | 200 mcg | Twice daily | 6 units | Strong GH pulse |
| Advanced | 300 mcg | 2–3× daily | 9 units | Peak GH stimulation; cortisol risk |
Reconstitution Steps
- Draw 3.0 mL bacteriostatic water.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl until dissolved. Do not shake.
- Refrigerate at 2–8°C; use within 28 days.
Supplies Planning
| Item | 8 Weeks (2×/day) | 12 Weeks (2×/day) |
|---|---|---|
| GHRP-2 vials (10 mg each) | 5–6 vials | 8–9 vials |
| Insulin syringes (30–50 unit) | 112 | 168 |
| Bacteriostatic water (10 mL) | 2 × 10 mL | 3 × 10 mL |
| Alcohol swabs | 2–3 × 100-pack | 3–4 × 100-pack |
Mechanism of Action
GHRP-2 (pralmorelin) is a synthetic hexapeptide that acts as a ghrelin receptor (GHS-R1a) agonist. It stimulates GH release through two complementary pathways: directly at the pituitary and by amplifying GHRH release from the hypothalamus. This dual-site action makes it one of the most potent GHRPs studied.
GHRP-2 produces robust GH pulses with peak concentrations at approximately 15–30 minutes post-injection. Unlike ipamorelin, GHRP-2 can produce dose-dependent cortisol and prolactin elevation, particularly at doses ≥300 mcg. This limits its utility in extended protocols where adrenal axis interference is a concern. When combined with GHRH analogs (CJC-1295, Sermorelin), GH pulse amplitude is dramatically amplified through complementary receptor pathway activation.
Research Findings & Safety Profile
- One of the most potent GHRPs studied; produces robust, dose-dependent GH pulses.
- Approved in Japan as a GH stimulation test agent (pralmorelin) at 100 mcg IV.
- Unlike ipamorelin, elevates cortisol and prolactin at doses ≥300 mcg — requires monitoring in extended protocols.
- Synergistic GH amplification when combined with GHRH analogs.
- Increased appetite and hunger — stronger than ipamorelin due to broader ghrelin receptor effects.
- Possible effects: water retention, tingling, increased appetite, transient cortisol elevation at high doses.
Storage
| State | Temperature | Duration | Notes |
|---|---|---|---|
| Lyophilized | −20°C (−4°F) | Up to 24 months | Dry, dark, minimize moisture |
| Reconstituted | 2–8°C (35–46°F) | Up to 28 days | Avoid freeze-thaw |