📈 IGF-1 Analog

IGF-1 LR3 (1 mg Vial) Dosage Protocol

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a synthetic analog of human IGF-1 with two structural modifications: an N-terminal 13-amino acid extension and a glutamate-to-arginine substitution at position 3. These changes dramatically reduce IGF-1 binding protein affinity, extending the half-life from ~10 minutes to approximately 20–30 hours.

⚡ Quickstart Highlights

Reconstitution

1.0 mL BAC water → 1,000 mcg/mL (1 mg/mL)

Per-Dose Range

20–100 mcg per injection

1 U-100 Unit =

10 mcg

Half-life

~20–30 hours

Dosing & Reconstitution Guide

Route: Subcutaneous or IM | Frequency: Once daily during active cycle

Protocol	Dose Per Day	U-100 Units	Volume	Notes
Conservative	20–40 mcg/day	2–4 units	0.02–0.04 mL	Use 30-unit syringe for precision
Standard	50–80 mcg/day	5–8 units	0.05–0.08 mL	Common research range
Advanced	80–100 mcg/day	8–10 units	0.08–0.10 mL	Upper research limit; monitor glucose

Volume warning: Doses are very small (0.02–0.10 mL). Use a 30-unit (0.3 mL) insulin syringe for much better accuracy than a standard 100-unit syringe. At 1 mg/mL, every 10 mcg = 1 syringe unit = 0.01 mL.

Reconstitution Steps

Draw 1.0 mL bacteriostatic water into a sterile syringe.
Inject slowly down the inside glass wall of the vial; avoid foaming.
Gently swirl until dissolved. Do not shake.
Label with reconstitution date. Refrigerate at 2–8°C; use within 28 days.

Supplies Planning

Item	4-Week Cycle (50 mcg/day)	6-Week Cycle
IGF-1 LR3 vials (1 mg each)	2 vials	3 vials
Insulin syringes (30-unit)	28	42
Bacteriostatic water (10 mL)	1 × 10 mL	1 × 10 mL
Alcohol swabs	1 × 100-pack	1 × 100-pack

Mechanism of Action

IGF-1 LR3 is a recombinant analog of insulin-like growth factor 1, modified with an N-terminal 13-amino acid extension (the 'Long' component) and a Glu-3→Arg substitution (the 'R3' component). These modifications dramatically reduce the binding affinity of IGF-1 to its six binding proteins (IGFBPs), which in natural IGF-1 sequester approximately 99% of circulating IGF-1 in an inactive bound form. By reducing IGFBP binding, IGF-1 LR3 remains in free, biologically active form for much longer — extending the half-life from ~10 minutes (native IGF-1) to approximately 20–30 hours.

IGF-1 LR3 acts directly at IGF-1 receptors and insulin receptors in muscle, bone, and other tissues, promoting amino acid uptake, protein synthesis, satellite cell activation (muscle stem cells), and anti-catabolism. Unlike GH secretagogues which work upstream through the pituitary, IGF-1 LR3 acts at the downstream effector level — bypassing the GH axis entirely.

Research Findings & Safety Profile

Extended half-life (20–30 hr) vs natural IGF-1 (~10 min) due to dramatically reduced IGFBP binding.
Promotes muscle protein synthesis, satellite cell activation, and anti-catabolism in preclinical models.
Hypoglycemia risk: IGF-1 LR3 has significant insulin-receptor cross-activity. Monitor blood glucose; do not administer without access to fast-acting carbohydrates.
Potential for abnormal tissue growth with chronic supraphysiological dosing — not suitable for extended continuous cycles.
Typical research cycles: 4–6 weeks maximum; extended use increases hypoglycemia and tissue proliferation risk.
WADA prohibited. Not FDA approved for any indication in this form.

Storage

State	Temperature	Duration	Notes
Lyophilized	−20°C (−4°F)	Up to 24 months	Dry, dark conditions
Reconstituted	2–8°C (35–46°F)	Up to 28 days	Avoid freeze-thaw; protect from light

⚠ Research Use Only: IGF-1 LR3 is one of the more risk-significant compounds on this site due to its hypoglycemia potential and tissue proliferation concerns. Use 30-unit syringes for precision. Limit cycle length. Monitor blood glucose. WADA prohibited.

References

Tomas FM et al. 'Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats' — Biochem J, 1993 View source ↗

Francis GL et al. 'Insulin-like growth factors 1 and 2 in bovine colostrum: sequences and biological activities' — Biochem J, 1988